منابع مشابه
Chromosomal passengers
Not to be confused with... CENP-E, chromokinesin, Polo kinase... A number of proteins are localised a bit like chromosomal passengers. However these proteins occupy slightly different locations on the chromosomes: the kinetochore for CENP-E and Polo; all along the chromosome arms for chromokinesin. Some of these proteins may interact functionally or physically with the passenger proteins. Stran...
متن کاملCytokinesis: the final stop for the chromosomal passengers.
The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned since then about the role of the CPC in the late stages of mitosis and cytokine...
متن کاملStructure of a Survivin–Borealin–INCENP Core Complex Reveals How Chromosomal Passengers Travel Together
The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the k...
متن کاملPassengers operate the brakes
Passengers operate the brakes M embers of the chromosome passenger complex (CPC) regulate kinesin motors to control how fast the mitotic spindle elongates , Rozelle et al. report. The CPC consists of the mitotic kinase Aurora B and its associated regulatory proteins. The complex localizes to kinetochores at the beginning of mitosis and regulates their attachment to the mitotic spindle. The CPC ...
متن کاملFrom passengers to drivers
Microbes have several mechanisms that promote evolutionary adaptation in stressful environments. The corresponding molecular pathways promote diversity through modulating rates of recombination, mutation or influence the activity of transposable genetic elements. Recent experimental studies suggest an evolutionary conflict between these mechanisms. Specifically, presence of mismatch repair muta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00407-9